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Sport is not always a level playing field because some athletes take illegal performance-enhancing drugs. Such “doping” can not only give athletes advantages over others and potentially impact upon the reputation of sport, but it can also carry serious health risks. As such, worldwide anti-doping organizations enforce testing for banned substances in athletes, which often includes the use of high-performance liquid chromatography (HPLC) for the highly sensitive analysis of drug testing samples. Yet, ultrapure water is essential for the effective operation of HPLC.