Skip to main content
Home

Dedicated to discovery

  • Company
    • About us
    • Careers
    • Events
  • Support
    • Laboratory Planning
    • Register a Product
    • Register Your Product (USA & Canada Only)
  • Contact
  • U.S.A.
  • Deutschland
  • España
  • France
  • Italia
  • Brasil
  • 日本
  • 中国
Home
  • Products
    • PURELAB®
      • PURELAB® Quest
      • PURELAB® Pharma Compliance
      • PURELAB® Chorus 1 Complete
      • PURELAB® Chorus 1
      • PURELAB® Chorus 2
      • PURELAB® Chorus 2 +
      • PURELAB® Chorus 3
      • PURELAB® flex 1
      • PURELAB® flex 2
      • PURELAB® flex 3
      • PURELAB® flex 4
      • PURELAB® flex 5
    • CENTRA®
      • CENTRA® R60/120
      • CENTRA® R200
      • CENTRA® RDS
    • MEDICA®
      • MEDICA® 7/15
      • MEDICA® Pro-R & Pro-RE
      • MEDICA® R200
      • MEDICA® EDI 15/30
      • MEDICA® Pro-LPS
      • MEDICA® Pro EDI 60/120
      • MEDICA® BIOX
      • Hubgrade
    • BIOPURE®
      • BIOPURE® 300/600
    • ELGA Full Product Range
      • PURELAB® Classic
  • Applications
    • Atomic Absorption Spectroscopy
    • Cell and Tissue Culture
    • Clinical Biochemistry
    • Electrochemistry
    • Gas Chromatography
    • General lab water requirement
    • Immunochemistry
    • Liquid Chromatography
    • Mass Spectrometry
    • Microbiology
    • Molecular Biology
    • Spectrophotometry
  • Technologies
    • Activated Carbon
    • Electrodeionization (EDI)
    • Filtration
    • Ion Exchange
    • PureSure
    • Reverse Osmosis
    • Ultraviolet
  • Impurities In Water
    • Dissolved Gases
    • Inorganic Compounds
    • Microorganisms & Bacteria
    • Organic Compounds
    • Particulates
  • Knowledge
    • Blog
    • Case Studies
    • Ultrapure water
    • Guides and White Papers
  • Where to buy
  • Contact us
Home
  • Contact us
  • Products
    • PURELAB®
      • PURELAB® Quest
      • PURELAB® Pharma Compliance
      • PURELAB® Chorus 1 Complete
      • PURELAB® Chorus 1
      • PURELAB® Chorus 2
      • PURELAB® Chorus 2 +
      • PURELAB® Chorus 3
      • PURELAB® flex 1
      • PURELAB® flex 2
      • PURELAB® flex 3
      • PURELAB® flex 4
      • PURELAB® flex 5
    • CENTRA®
      • CENTRA® R60/120
      • CENTRA® R200
      • CENTRA® RDS
    • MEDICA®
      • MEDICA® 7/15
      • MEDICA® Pro-R & Pro-RE
      • MEDICA® R200
      • MEDICA® EDI 15/30
      • MEDICA® Pro-LPS
      • MEDICA® Pro EDI 60/120
      • MEDICA® BIOX
      • Hubgrade
    • BIOPURE®
      • BIOPURE® 300/600
    • ELGA Full Product Range
      • PURELAB® Classic
  • Applications
    • Atomic Absorption Spectroscopy
    • Cell and Tissue Culture
    • Clinical Biochemistry
    • Electrochemistry
    • Gas Chromatography
    • General lab water requirement
    • Immunochemistry
    • Liquid Chromatography
    • Mass Spectrometry
    • Microbiology
    • Molecular Biology
    • Spectrophotometry
  • Technologies
    • Activated Carbon
    • Electrodeionization (EDI)
    • Filtration
    • Ion Exchange
    • PureSure
    • Reverse Osmosis
    • Ultraviolet
  • Impurities In Water
    • Dissolved Gases
    • Inorganic Compounds
    • Microorganisms & Bacteria
    • Organic Compounds
    • Particulates
  • Knowledge
    • Blog
    • Case Studies
    • Ultrapure water
    • Guides and White Papers
  • Where to buy
  • Contact us
  • Company
    • About us
    • Careers
    • Events
  • Support
    • Laboratory Planning
    • Register a Product
    • Register Your Product (USA & Canada Only)
  • Contact
  • U.S.A.
  • Deutschland
  • España
  • France
  • Italia
  • Brasil
  • 日本
  • 中国
  • Privacy policy
  • Terms & Conditions
  • Global Legal Compliance
  • Patents
  • Trademarks
  • Impressum

Let's talk about lab water

  • Categories
    • Analytical Chemistry
    • Biotechnology
    • Clinical & Pharma
    • Cool Science
    • Environment & Sustainability
    • Future Science
    • Life in The Lab
    • Life Science Results
    • PURELAB Product Design
    • Science of the Future
    • Water In The Lab
    • Water Purity
  • Authors
    • ELGA Editorial Team_cloned
    • ELGA Editorial Team
    • Natasha Zarach
    • Dr Paul Whitehead
    • Dr Alison Halliday
    • John Walker
Clinical & Pharma
Cool Science

Identifying antibacterial compounds in industrial hemp

9 Mar 2023
- by Dr Alison Halliday

Identifying antibacterial compounds in industrial hemp

Researchers identify two hemp compounds with antibacterial activity that offer promise for a variety of applications in the food, pharmaceutical and cosmetic industries.

Hemp (Cannabis sativa), or industrial hemp, is an annual herbal plant of the cannabis species that is grown for industrial or medicinal applications. Hemp-derived extracts from the seeds, flowers, leaves or stems are used to make a range of different products – including paper, textiles, biodegradable plastics, biofuel, food and animal feed.

Some natural fibre plants, including hemp, are known to possess antimicrobial activity against a wide range of disease-causing bacteria. As a result, industrial hemp is attracting increasing attention in the search for new classes of antimicrobial agents to combat the rising global health threat of antibiotic resistance. But the potential applications for hemp-derived materials with antibacterial properties extend beyond medications – for example, as natural preservatives in food packaging and cosmetics.

Although there is much anecdotal evidence for the antimicrobial activity of hemp extracts, more rigorous laboratory investigations are needed - to identify the active components and understand their mechanisms of action.

Hemp leaf extract

In a new study, published in Separations, researchers set out to isolate and identify compounds with antibacterial activity from industrial hemp leaves.1

The team screened the antibacterial activity of hemp leaf extract against three species of bacteria: Escherichia coli, Staphylococcus aureus, and Bacillus cereus. They found the hemp leaf extract was highly effective at preventing the growth of E. coli and S. aureus – with a minimum inhibitory concentration of 12.5 mg/ml against both organisms. However, it did not affect the growth of B. cereus.

The researchers separated the hemp leaf extract into fractions using high-performance liquid chromatography (HPLC) and screened these for activity against E. coli – identifying two fractions with significant antibacterial activity. Using analytical HPLC, they went on to reveal the identity of the two active compounds as cannabidivarinic acid and cannabidiolic acid.

The team then performed a series of experiments to explore the mechanism of action of these compounds. Both substances destroyed the bacterial cell wall and membrane – resulting in the inhibition of enzyme activity and leakage of contents. Morphological evaluation of the bacterial cell surface using transmission electron microscopy also revealed damage to the cell envelope.

The researchers used deionised water generated by an ELGA laboratory water purification system in these experiments, minimising the risk of introducing contaminants that may affect their results.

Natural preservatives

This study presents evidence of the antibacterial activity of industrial hemp leaf extract on E. coli and S. aureus. Bioassay-guided fractionation and isolation led to the identification of two compounds – cannabidivarinic acid and cannabidiolic acid – which can prevent the growth of E. coli.

The discovery that cannabidivarinic acid and cannabidiolic acid possess antibacterial activity makes these compounds good candidates for a variety of applications in the food, cosmetic and pharmaceutical industries.

Why choose ELGA LabWater

ELGA LabWater has been a trusted name in pure and ultrapure water since 1937. Our dedication to ultrapure and pure water is a guarantee that we will continue to provide the best solutions with the best service.




Reference:

  1. Garcia-Flores V. et al. Preparation of single-cell suspensions from the human placenta. Nat. Protoc. (2022) https://doi.org/10.1038/s41596-022-00772-w/li>



Dr Alison Halliday

After completing an undergraduate degree in Biochemistry & Genetics at Sheffield University, Alison was awarded a PhD in Human Molecular Genetics at the University of Newcastle. She carried out five years as a Senior Postdoctoral Research Fellow at UCL, investigating the genes involved in childhood obesity syndrome. Moving into science communications, she spent ten years at Cancer Research UK engaging the public about the charity’s work. She now specialises in writing about research across the life sciences, medicine and health.


 

Explore more from our blog

27 Mar 2023
How does a plant-based diet affect the mineral content of breast milk?
9 Mar 2023
Identifying antibacterial compounds in industrial hemp
27 Feb 2023
Single-cell suspensions from the human placenta
16 Jan 2023
Measuring the effects of indoor air pollution
10 Jan 2023
A novel approach to wound healing
12 Dec 2022
3D bioprinting probiotics capsules
4 Nov 2022
Wie mikrobielle Brennstoffzellen zur Lösung von zwei dringenden globalen Umweltproblemen beitragen könnten
24 Oct 2022
New ‘designer drug’ identified in e-cigarettes

Blog Categories

  • Analytical Chemistry
  • Biotechnology
  • Clinical & Pharma
  • Cool Science
  • Environment & Sustainability
  • Future Science
  • Life in The Lab
  • Life Science Results
  • PURELAB Product Design
  • Science of the Future
  • Water In The Lab
  • Water Purity

Related Content

Hemp Seed
Could Hemp Seeds Provide A Natural Sleep Aid?

Related Products

Related
PURELAB® Quest
The only purifier on the market that dispenses all 3 types of science ready water from a compact
PURELAB Chorus 1
PURELAB® Chorus 1
Delivering the ultimate in water purity • Type 1+ Water •18.2 MΩ.cm • 1-120 Liters per day
HPLC in Pharma Analysis White Paper

White Paper: HPLC in Pharma Analysis

Learn how HPLC can help you meet the specific challenges related to water for pharmaceutical use.

  • Learn more
  • Enquiry
  • Get a Quote
  • Book a Demo
  • Find an Approved Partner

Enquiry

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

Get a Quote

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

Book a Demo

Please check this to confirm that you have read our Terms of Service and Privacy Policy.

Call us

Can't find what you are looking for?

Support Number
+44 (0)20 3567 7300
United Kingdom Sales
+44 (0)1628 879 704
United States of America Sales
+1 877-315-3542
France Sales
+33 1 40 83 65 00
China Sales
+86 400-616-8882

 

ELGA LabWater US Headquarters

ELGA LabWater North America
5 Earl Ct Suite 100
Woodridge, IL 60517
USA

Tel: 630-343-5251

ELGA LabWater UK Headquarters

Lane End Business Park
Lane End, High Wycombe
HP14 3BY
United Kingdom
T: +44 (0) 203 567 7300
F: +44 (0) 203 567 7205

Case Studies

  • Abbott Diagnostics
  • DASA Medical Diagnostics
  • NeoDIN Medical Institute
  • North Staffordshire NHS Trust
  • Olsberg Vocational College

Resources

  • Learn About Ultrapure Water
  • Guides and White Papers
  • Purification Technologies
  • Applications
  • Impurities In Water

Blogs

  • Latest Blog
  • Water Purity - Different Types of Pure Water
  • What is Clinical Laboratory Reagent Water (CLSI)?
  • What is Total Organic Carbon (TOC)?

© VWS (UK) Ltd. trading as ELGA LabWater. 2023 - All rights reserved.
ELGA is the global laboratory water brand name of Veolia.

  • Privacy policy
  • Terms & Conditions
  • Global Legal Compliance
  • Patents
  • Trademarks
  • Impressum
  • Language
    • Deutsch
    • English
    • Español
    • Français
    • Italiano
    • Português
    • 日本語
    • 中文
  • Other Veolia Sites
    • Veolia
    • Veolia Foundation
    • Veolia Water Technologies
Elga Veolia
TOP

© 2017 ELGA Veolia