Save time and reduce risk with easier tools for TOC, BET, Conductivity and Bioburden.

Manufacturers and facilities around the world need simpler and more efficient analytical testing solutions for quality control and process monitoring. From pharmaceutical manufacturing to wastewater treatment, chemical production to semiconductor fabrication -- complex measurements need to be simplified, and compliance cannot be compromised.

That's why we've developed analytical solutions that go beyond just testing -- delivering the actionable insights and efficiency you need for robust process control, proactive risk management, and uncompromising quality assurance. Through laboratory analysis or continuous real-time monitoring, our approach reduces operational risk while ensuring regulatory compliance.

We understand your challenges and bring decades of expertise alongside our comprehensive portfolio of Sievers Analytical Instruments -- including TOC analyzer, bacterial endotoxin testing and bioburden testing equipment -- to streamline both your laboratory operations and manufacturing processes.

Solutions for monitoring:

Total Organic Carbon (TOC)
Bacterial Endotoxin Testing (BET)
Rapid Bioburden
Conductivity
Boron

Expertise in:

Compendial water testing
Quality control
Process control
Cleaning validation
Risk mitigation
Rapid methods
Contamination control
Real-time testing
Discharge compliance

Industries we support:

Pharmaceutical & Biopharmaceutical
Cosmetics & Personal Care
Medical Device
Microelectronics
Drinking Water & Environmental / Wastewater
Chemical
Food & Beverage
And more

For over 40 years, Sievers solutions have set the global standard for analytical excellence, establishing the portfolio as the world's leading provider of TOC and conductivity analyzers. Our proven technology delivers unmatched precision, reliability, and performance -- which is why industry leaders across pharmaceuticals, semiconductors, chemical processing, and beyond trust Sievers as their critical measurement partner.

From instruments and software to consumables, services, and technical expertise, we provide the complete analytical ecosystem that transforms complex testing into streamlined, compliant operations. When you choose Sievers Instruments, you gain the confidence that comes from working with the market leader -- ensuring your products meet the highest standards of safety, quality, and regulatory compliance.

Get Expert Guidance on Your Testing Needs→

What Is Compendial Water Testing?

Compendial water testing is the set of pharmacopeial methods -- Total Organic Carbon (TOC), Bacterial Endotoxin Testing (BET), conductivity and bioburden -- that pharmaceutical, biopharmaceutical and medical device manufacturers use to demonstrate their water systems meet USP, EP and other regulatory water-quality standards.

Sievers instruments cover the full compendial testing lifecycle: TOC and conductivity for routine water-system monitoring, BET for endotoxin risk and rapid bioburden for microbial contamination -- so a single analytical partner can support both laboratory testing and continuous, real-time process monitoring.

See the full compendial testing overview →

A TOC analyzer is often the first instrument facilities add when building out compendial testing capability, since Total Organic Carbon is one of the most frequently required water-quality tests across USP, EP and other pharmacopeial standards.

Which Test Method Applies to Your Compliance Requirement?

Each analytical method below maps to a specific compendial chapter or regulatory expectation.

Method	Regulatory Reference	What It Measures
Total Organic Carbon (TOC)	USP <643>	Organic carbon contamination in pharmaceutical water systems, as a proxy for overall water purity
Conductivity	USP <645>	Ionic/inorganic contamination in water for pharmaceutical use
Bacterial Endotoxin Testing (BET)	USP <85>	Bacterial endotoxin levels, a key pyrogen risk in parenteral products and water systems
Rapid Bioburden	General microbial limits (chapter not specified in source material)	Total viable microbial load, tested faster than traditional culture-based methods
Boron	IRDS 50 ppt limit (semiconductor UPW spec, not a USP chapter)	Boron contamination in ultrapure water, relevant to semiconductor and microelectronics manufacturing

Frequently Asked Questions

What is Total Organic Carbon (TOC) testing and why does it matter for pharmaceutical water?: TOC testing (USP <643>) measures organic carbon contamination in pharmaceutical water systems as a proxy for overall water purity. It’s one of the most widely required compendial tests for water used in drug manufacturing.
What is Bacterial Endotoxin Testing (BET)?: BET (USP <85>) detects bacterial endotoxins -- a major pyrogen risk -- in water and parenteral products. It’s a critical release test for injectable and other sterile pharmaceutical products.
What’s the difference between a TOC sensor and a TOC analyzer?: A TOC sensor typically provides continuous, in-line monitoring with less analytical detail, while a TOC analyzer delivers laboratory-grade precision for compendial compliance testing. Which one you need depends on whether you’re monitoring a process in real time or generating data for regulatory release.
How does rapid bioburden testing differ from traditional bioburden methods?: Rapid bioburden testing equipment detects microbial contamination faster than traditional culture-based testing, which can take several days to produce results. That speed lets manufacturers catch contamination issues sooner and release product with less delay.